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Nevertheless, several cellular studies have suggested the protective roles of chemical anti-oxidants, such as GSH, as well as drug metabolizing enzymes, such as NQO1 and UDP-glucuronosyltransferases (UGTs), against AQ-induced cytotoxicity ( HepG2 cells have been used for decades as a test system for studies involving hepatotoxic compounds

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Mechanism for Extraesophageal Symptoms The mechanism for extraesophageal manifestations of GERD, such as wheeze or cough, may not always be direct aspiration or damage of mucosa in the respiratory tract but a vagally mediated reflex triggered by acidification of the distal esophageal mucosa

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Higher morning HRV generally correlates with better restorative sleep